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Due to their cytotoxic effects, the majority of HDACis are approved for use in hematological and neoplastic malignancies [89]
A randomized trial with 60 healthy participants revealed that cocoa consumption significantly reduced serum levels of trimethylamine N-oxide (TMAO) and uric acid, while enhancing flow-mediated vasodilation

IUBMB Life 60 (7), 421429

Supplementing with adenosine, an ATP precursor, effectively restores cellular energy metabolism and function, offering a novel energy supplementation strategy to promote renal injury repair [311]

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