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This finding is consistent with build-up of the reactive electrophiles, maleylacetoacetate and maleylacetone, and suggests that chemical knock-down of GSTZ1 by DCA will have similar effects

Besides the advantage of substituting fetal calf serum (43) the human serum/plasma samples contain all bioavailable constituents and metabolites at physiological concentrations

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However, neutrophilic inflammation is the dominant endotype in COPD patients [36] and the neutrophilic inflammatory pathway responds poorly to corticosteroids [37]

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