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The formation of these INH hydrazones might affect the metabolism of amino acids, but their role in INH hepatotoxicity still needs further investigation

Supplementary Table 11 (download XLSX Cell population-specific differential gene expression analysis results of rat and mice across all available treatment

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The high K M , for glucose, of hepatic glucokinase allows the liver to buffer blood glucose

In addition, compartmental or PBPK-based modeling may improve the interpretation of nanocarrier distribution, particularly for systems with formulation-dependent or nonlinear pharmacokinetics (Yuan et al., 2019