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Maintaining an optimal level of glutathione appears to be important for supporting cognitive function, especially during aging.* The normal process of aging is associated with a decrease in glutathione activity, which can result in increased oxidative activity.* Less than an optimum level of glutathione is observed in individuals experiencing a decline in cognitive function.* Conversely, individuals who live to 100 tend to have higher glutathione activity.*

Methods We used a mouse model of global Taz knockdown (Taz-KD) and combined in vivo and in vitro approaches to assess pancreatic islet metabolism, morphology and hormone secretion