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CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life
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It also reduces fatigue
Silicon implants might also be used which are removable
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The mutant receptors also recover faster from desensitized state compared to wild-type with rec of 0.3 s (**P = 0.0028) and 0.6 s (*P = 0.0465) for E239L and Y243F respectively
