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Furthermore, we observed that overexpression of GPX3 could inhibit the proliferation of prostate cells, induce G0/G1 phase arrest, cell apoptosis, MMP dissipation and cytoplasmic transfer of Cyto-C

As a core metabolic product, lactate may promote the release of inflammatory mediators (e.g., IL-6, TNF-) by activating the TGF- signaling pathway, while enhancing NF-B pathway activity to exacerbate local inflammatory infiltration in lung tissue but this direct activation has not been demonstrated in COPD airway cells

We examined whether genetically based deficiency of cellular glutathione peroxidase, a major antioxidant enzyme, increases noise-induced hearing loss in mice

doi: 10.1023/a:1005507913372

doi: 10.1111/ajd.13186 404 LiLHanZNiuXZhangGJiaYZhangSet al

264,265 Both PMOs and PNAs are neutral nucleic acid analogs with weak binding to plasma proteins, allowing them to be easily cleared by the kidneys