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(PMID: 24684379) Ruttmann, Brant, Concin, and colleagues followed 163,944 Austrian adults for up to 17 years and published their findings in Circulation in 2005

An imbalance in favor of antioxidants can lead to so-called antioxidative stress, which may also have harmful effects, particularly when synthetic antioxidants are consumed in excessive amounts [165]

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and more atypical routes

The expression of different isoforms of the enzymes of ascorbate-glutathione pathway is developmentally as well as spatially regulated

Glutathione may be beneficial for protecting cells and tissues from damage by heavy metal toxicity and other environmental toxins, breaking them down into less harmful compounds so the body can rid itself of them