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What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide

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Options include: Fortified foods : Nutritional yeast, plant-based milk alternatives, breakfast cereals, and meat substitutes fortified with B12 (check labels for content) Supplements : Daily supplements of 10 mcg or weekly doses of 2,000 mcg ensure adequate intake, as recommended by the British Dietetic Association The body absorbs approximately 50% of a 12 mcg dose but only about 1% of a 1,000 mcg dose through passive diffusion

341 Schwann cell injury In DPN, hyperglycemia and oxidative stress lead to Schwann cell dysfunction and apoptosis, resulting in demyelination and impaired nerve conduction