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Resveratrol, a sirtuin-activating compound, enhances the activity of the SIRT1-PGC-1 axis and promotes muscle remodeling in mice with Duchenne muscular dystrophy [170]
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The PFCD cohort exhibited significantly lower total serum amino acid concentrations compared to CAF group, with 13 differentially expressed amino acids identified

doi: 10.1016/j.tox.2004.11.019

A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being a strong biochemical oxidizer
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