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Persistent cellular damage provokes an inflammatory response that recruits innate immune cells (particularly macrophages) to the site of injury and elicits the release of pro-fibrotic factors, such as transforming growth factor (TGF-) and -smooth muscle actin (-SMA) [13]

Some solid cancers also exhibited high level of GPX4 expression including melanoma, gastric, endometrial, prostate and colorectal cancers

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[Abstract]2021 Mar 20;11(11):5605-5619

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For example, platinum (IV) prodrugs activated by intracellular GSH have demonstrated enhanced tumor selectivity and reduced systemic toxicity in clinical trials