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doi: 10.3389/fmicb.2021.732270 37 GrimwadeJ

Patent 5,482,856

Endoplasmic reticulum-mitochondrial calcium transport contributes to soft extracellular matrix-triggered mitochondrial dynamics and mitophagy in breast carcinoma cells

In the glyoxalase pathway, glyoxalase I (GLXI) converts methylglyoxal and GSH to S-D-lactoylglutathione which is converted by glyoxalase II (GLXII) to D-lactate, liberating GSH

The hydrolyzed form is intended to support absorption, skin hydration, and elasticity

BPC-157 and similar "performance peptides" marketed for muscle recovery lack human validation despite extensive preclinical data
