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Description
Lancet Neuro

As it can be easier for their body to absorb supplements than naturally occurring vitamin B12, older adults should aim to meet their vitamin B12 needs through fortified foods and vitamin supplements
The interface with the second largest buried surface area in the Tyk2 crystal lattice did place the C- and N-termini in close enough proximity to be linked by the interdomain linker, and this interface was investigated in detail and mutational data did support the biological significance of this interaction surface

A key extrinsic pathway component is the death receptor Fas (CD95), which, upon binding to Fas ligand (FasL/CD95L), recruits the adaptor protein FADD (Fas-associated death domain protein) and procaspase-8 to form the death-inducing signaling complex (DISC)

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Hippocampal neurons were then cultured a further 3-7 days, at which time they were either transfected or treated with various pharmacological reagents as described in the text or figure legends
