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Endocrinology 157 , 11461162 (2016)

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Moreover, CB-839 has been demonstrated to inhibit myeloma cell proliferation and enhance sensitivity to histone deacetylase (HDAC) inhibitors, suggesting that CB-839 has potential as a therapeutic agent for patients with MM [141]

It is unclear precisely what the changes in electrophoretic mobility represent for these various forms of phospho-Tau, but most likely they reflect changes in phosphorylation at other sites on the molecule