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Native, unmodified peptides are typically cleaved rapidly by serum dipeptidyl peptidase-4 (DPP-4), neutral endopeptidase, and aminopeptidases

Int J Pharm 396:143148 Trepanier DJ, Gallant H, Legatt DF, Yatscoff RW (1998) Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update

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Both have garnered attention for their effectiveness in revitalizing the skin and reducing the appearance of fine lines and wrinkles