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The above evidence suggests that antioxidant therapy may not show a good effect in advanced HCC with severe abnormal liver function

Antioxidant and anti-inflammatory signalling: Published research has shown interactions with antioxidant defence systems and inflammatory signalling pathways in laboratory models, including modulation of pro-inflammatory cytokine activity and upregulation of antioxidant enzyme expression

The oxidation of arachidonic acid proceeds by various reactions resulting in the formation of various products

Further more, oxidized DNA is more resistant to degradation by cytosolic nucleases ( In agreement with the described role for oxidants in senescence, peroxiredoxins (PRX), which are well-known antioxidant enzymes, have been shown to protect cells from senescence and to participate in the SASP

Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP, Brisken C

gingivalis colonization at the gingival margin and adjacent alveolar bone, a setting in which bacterial virulence and host inflammatory responses promote iron accumulation, mitochondrial dysfunction, lipid peroxidation and ultimately ferroptotic cell death