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First, investigators discovered that one bulk active ingredient came from a supplier not listed in the FDAs registration database

J Leukoc Biol (2019) 106:36983
It was first identified in human plasma in the early 1970s by Dr

e-Pub 1998

IMQ application successfully induced psoriasis-like lesions in C57BL/6 mice, with characteristic pathological features evident in the model group (Fig