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The metabolic alterations are associated with increased expression of the ectoenzyme CD38 on CMV-specific CD8 + T cells

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Moreover, CMV-specific CD8 + T cells of noncontrollers were marked by an increased mitochondrial mass, which has been attributed to defects in proteasome and autophagic lysosome-dependent protein turnover in dysfunctional T cells (18, 37)

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