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Discovery and preclinical development of Netarsudil, a novel ocular hypotensive agent for the treatment of glaucoma

Adaptive immunity is represented by B and T lymphocytes providing antigen-specific responses ( Epigenetic regulation of the immune system.Epigenetic modifications are functionally connected to the differentiation, activation, function, and exhaustion of immune cells ( Supplementary Figure 1 )

In addition, doxorubicin was applied in multiple dosages (3 mg/kg s.c., once weekly through 13 weeks) and in single dosages (7 mg/kg, i.v.) and provoked cardiomyopathy

usually mild-to-moderate and easing with time [2] [4]

Vgontzas AN, Bixler EO, Chrousos GP