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Colistin was introduced in the clinic in 1961 with the expectation, by the scientific community, of finally filling the void in the treatment of challenging infections such as those from antibiotic resistant Pseudomonas aeruginosa [4]

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Penetration through the skin barrier is limited, particularly for larger molecules, and results depend heavily on the delivery vehicle and formulation

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Still, they noted a decrease in IL-17, which in our mice was elevated in both a nave and infected cyanocobalamin-supplemented groups