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Also due to literature uncertainty and potential biological variability, the scaling of blood nutrients in aging was based on the expectation of only a mild increase in blood glucose and proportional changes in blood lactate

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Pseudohypoxia, a phenomenon originally observed in diabetic conditions, refers to a metabolic state resembling hypoxia despite normal levels of oxygen (Williamson et al., 1993)

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Peripherally restricted analgesics that target only peripheral opioid receptors, but not those in the central nervous system, could provide sufficient analgesia ( Sleep loss/deprivation as a modulator of the opioid mediated analgesia Numerous studies have investigated the impact of experimental sleep disturbances on pain perception (Moldofsky, 1995