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The dysregulation of this pathway has been identified to promote CSCs renewal, cell proliferation, and differentiation, and is closely related to CRC progression and treatment resistance (Yamamoto et al., 2022

Nevertheless, currently available DNMT inhibitors are not sufficiently selective, leading to off-target adverse effects including global DNA hypomethylation, oncogene activation and increased genomic instability

J Nutr (1995) 125(2):293301

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So the delivery of GPx3 to breast tumor tissues through hiPSC-MSCs or other methods may promote its expression, and reduce the influence of ROS on the progression of breast cancer accordingly, finally achieve the goal of treating breast cancer