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Upon binding to the erythropoietin receptor (EpoR, located on the surface of erythroid progenitor cells), EPO activates Jak2/STAT5, Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways [41, 42] with consequent downstream recruitment of GATA-1 transcription factor [43], a master regulator of erythropoiesis critically affecting all aspects of cell survival and proliferation

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PubMed Fc gamma receptor (FcgammaR) coengagement can facilitate antibody-mediated receptor activation in target cells

Reactive oxygen species (ROS) exacerbate matrix degradation and promote further inflammation, establishing a self-sustaining loop of cartilage damage (Lepetsos and Papavassiliou, 2016

Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice

CJC-1295 and Ipamorelin stimulate endogenous HGH release, while AOD-9604 targets fat directly without affecting IGF-1