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The permeability of the NMDAR pore to the predominant intracellular and extracellular monovalent cations K + and Na + , respectively results in depolarization from the normal resting membrane potential of CNS neurons

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Overall, natural compounds show minimal systemic or organ toxicity at therapeutic doses, although mild side effects may occurcurcumin, for instance, has resulted in only minor gastrointestinal upset even at high doses [22, 30, 57]