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Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis

[PubMed: 24495617] 147

A dysregulated and functionally impaired microbiome tend to promote chronic low-grade inflammation, immune dysregulation, oxidative stress, DNA damage and metabolic rewiring, contributing to the carcinogenic effects of hr-HPV integrating oncogenes into the host genome

While the current research gaps limit our understanding of EDC-induced reproductive dysfunction, developing tools and experimental models to assess the aftermath of developmental toxicant exposure is paramount to formulating treatments as well as methods to block the effects of EDCs and reduce the incidence of reproductive disease development

Research has indicated that mitochondrial GSTs in humans play important roles in the detoxification of lipid peroxide and lipid metabolism [61]

however, the regulatory mechanism between lncRNA H19 and ferroptosis is unclear (Xu et al., 2023)