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632 Astrocytes are primary targets for noradrenergic innervation 633 that are provided by widespread projections of neurones located in locus coeruleus and are critical for cognitive functions

Patients with one nonfunctional CYP2D6 null allele ( *3 , *4 , *5 , *6 , *52 , *4xn ) and one low activity CYP2D6 allele ( *9 , *10 , *29 , *41 ) were grouped as IMs, patients with one or two functional copies of the CYP2D6 gene were grouped as EMs

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Am J Physiol 258 : C452C460