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Although urinary BDNF may not be the ideal effect biomarker to address CNS alterations due to its secretion by kidneys and bladder tissues ( As shown in Figure 1, there are some adverse outcome pathways (AOPs) that could support and explain these results

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IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a modified version of IGF-1 designed with an extended half-life and increased potency

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