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[DOI] [PubMed] [Google Scholar] 197.Shen X, Pattillo CB, Pardue S, Bir SC, Wang R, Kevil CG

110 Despite a number of studies that reported somewhat conflicting results regarding the different cardiac phenotypes in response to increased AKT activity, it has currently been recognized that short-term appropriate AKT activation leads to physiological cardiac hypertrophy, while long-term AKT activation or AKT overexpression causes pathological cardiac hypertrophy, interstitial fibrosis, and even heart failure

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10.1002/1873-3468.13123 43 HanY.TangX.ZhangY.HuX.RenL