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Circulating glutathione levels have been proposed as useful predictive biomarkers of cognitive decline in patients with neurodegenerative diseases [179]

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The lack of function of the enzymes of glutathione production in these conditions suggests that more efficient resolution of the effects of glutathione depletion may require the administration of the complete molecule as demonstrated in vitro in the HIV + macrophage study [52]

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Serum B12 concentrations decreased significantly with age, with values for those consuming fortified breakfast cereals being significantly higher than non-consumers, a trend that was independent of age and gender