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Sangle, Prerna, et al

Beyond simple structural differences, a physicochemical explanation explains differential susceptibility: the lipopolysaccharide (LPS)-rich outer membrane of Gram-negative bacteria forms a hydrated, highly anionic and amphipathic barrier that actively limits partitioning of hydrophobic phytochemicals into the inner phospholipid bilayer

Effect sizes were estimated from meta-analysis of the BioBank Japan, MGI, and HUNT results only due to the differing effect size units of the CKDGen consortium results

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