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Description
Human data are mostly limited to short-term interventions, and direct measurement of lysosomal activity or autophagic flux in clinical trials remains challenging due to the lack of standardized, non-invasive biomarkers [30]
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia
Kuragano M, Murakami Y, Takahashi M
The second principle is temporal separation
The study was approved by the national regulatory agency (the Federal Institute for Drugs and Medicinal Products [Bundesinstitut fr Arzneimittel und Medizinprodukte]) and the independent ethics committee of the Bavarian Chamber of Physicians
Ann Med Surg (Lond)
