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In primary SS renal tubulointerstitial injury, CD163-positive cells and high expression of HIF-1 were reported, where HIF-1 could promote macrophage polarization and participate in renal tubular injury, and early intervention to release HIF-1 could improve renal function in patients (197)

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Neurodegenerative diseases Mitochondrial dysfunction in Alzheimers disease (AD) includes mitochondrial dynamic changes, a decrease in ATP generation, increased oxidative stress, mitophagy damage and mtDNA mutation

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