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Recently, more direct metabolic manipulations in rodents have allowed for some new insights into how decreased glucose utilization reduces seizures

For example, some IL-17 inhibitors result in disease activity reoccurrence in patients due to increased levels of IL-22, GM-CSF, or both, but all maintain inflammatory circuits independently

[DOI] [PubMed] [Google Scholar] 70.Hussain Y., Abdullah Alsharif KF., Aschner M., Theyab A., Khan F., Saso L., Khan H

Journal of Medicinal Chemistry, 64(5), 2438-2452

Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small-cell lung cancer

This reflects disturbances in membrane metabolism but the exact variation pattern contrasts with results characterizing cDDP-resistance in ovarian cancer cells, which were characterized by increased levels of GPC (although confirming decreased levels of choline as described here) [13]
