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If theyre not, theyre unpredictable, because they act throughout the body

Its ability to eliminate free radicals may help people with diabetic peripheral neuropathy, who have pain, burning, itching, tingling, and numbness in arms and legs from nerve damage

The absence of FDA approval means no verified manufacturing standards, dosing protocols, or safety benchmarks exist for human use

The anti-inflammatory activity, capsaicin-induced somatosensory neurons damage counteraction [21], recovery of sciatic nerve after transection [22], and cultured enteric neurons and glial cells protection [23] have been all reported

Overall, the information garnered from kratom-associated polyintoxications and the in vitro inhibitory effects of kratom (and its alkaloids) on P450 and P-gp activity suggests a high likelihood of observing additional pharmacokinetic kratom-drug interactions that affect drug pharmacodynamics