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Only pathways with a false discovery rate (FDR) and adjusted p-values below 0.05, along with more than one associated metabolite (hits), were included

During the GPx cycle, ebselen selenol is oxidized to ebselen selenenic acid by hydroperoxides which is then recycled back to ebselen selenol by consuming thiols (Fig

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247,248 The key targets of the PI3K/AKT pathway and their related regulatory mechanisms are shown in Fig

This regulatory intervention correlated with measurably lower population-wide exposure levels, demonstrating the effectiveness of systematic emission control policies ( 6.4.2 Global standardization of EED risk assessment 6.4.2.1 International harmonization efforts World Health Organization-endorsed biomonitoring guidelines aim to standardize global EED risk assessment methodologies, improving cross-border exposure comparisons and policy coordination ( 6.5 Emerging challenges and research priorities in intervention development While current intervention strategies have demonstrated measurable benefits in reducing EED exposure, several fundamental challenges limit their broader implementation and effectiveness