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First, we climb to Campa Pass (16,730 ft), another significant challenge
In view of the pivotal role played by GSH in redox system and the relationship between oxidative stress and autophagy 68 , it is conceivable that GSH depletion-induced oxidative stress and lipid peroxidation may be a key point linking ferroptosis and autophagy in RPE cells
10.1083/jcb.147.1.185 94
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However, nickel affinity purifications are frequently used as a first step in an overall purification protocol that might also include ion-exchange, hydrophobic-interaction, or size-exclusion steps
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