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This observation is not surprising considering the loss of function of pVHL in a number of renal cancers leading to stabilization of HIF- and subsequent pseudohypoxic possibly resulting in an increased activity of GCLC and GCLM

3 Molecular mechanisms of GPX4 in OA 3.1 Upstream regulation of GPX4: System Xc GSH axis and Nrf2 pathway 3.1.1 Critical role of System Xc and GSH supply System Xc is a heterodimeric membrane transport protein composed of a catalytic subunit, SLC7A11, and a regulatory subunit, SLC3A2, linked by a disulfide bridge

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