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However, the F-statistic prioritizes sites with large overall DNAm differences across all cell types, which can lead to the over-selection of CpGs that strongly differentiate one or a few cell types while neglecting others, resulting in imbalanced discriminatory power within the panel

However, data on oral bioavailability is limited and may vary greatly depending on formulation

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10.1016/j.sajb.2009.12.006 395 StrobelN

On the basis of the complicated pathogenic mechanisms and unsatisfactory therapeutic outcome of DKD, determining the exact pathogenesis and developing appropriate treatment methods are quite necessary