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In this regard, transcriptome investigations have shown that genes linked to cell proliferation are significantly upregulated in dominant follicles, whereas genes linked to cell death and apoptosis are mostly expressed in subordinate follicles [80, 81, 214, 215]

[DOI] [PubMed] [Google Scholar] 35.Mzsik G

Therefore, it is not surprising that NAMPT is upregulated in these tumors, since cancer cells depend on its activity to satisfy their high NAD + demand

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However, clinical recommendations from the European League Against Rheumatism (EULAR) and other organizations point to a multidisciplinary point of view of FM and its treatment (Giorgi et al., 2023

Together, these data indicate that inhibition of oxidative substrate utilisation is an important adaptation to lipotoxicity