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Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus

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Epidemiology 2004

22,23,24 Improved performance of brain-targeted drug delivery was proved thanks to these materials with obvious advantages including non-invasive delivery, high drug loading, good biocompatibility, prolonged blood circulation, and importantly brain targeting effect

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