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We explored whether the GHK-Cu has an effect on the activation of p38 MAPK, ERK1/2, and JNK1/2 signaling molecules in LPS-induced RAW 264.7 macrophages in vitro and ALI in mice in vivo

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For our experiments we excluded rats that did not maintain those natural rhythm, and/or were apathetic (12 h mean value of motor activity was below 1.0 count during day-time and 2.5 counts during night-time)

As a drug delivery system, nano gels have several advantageous features for the PD, like high drug loading capacity, biocompatible nature, and safeguarding the encapsulated drugs from degradation (137, 138)

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Moreover, the severely affected rat exhibited DG with no hilum and the granular cells had been drastically reduced and became condensed, irregular and surrounded by large space
