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Where are you noticing changes

So, the focus should be on limiting the exposure

Impairment of Other Metabolic Processes Chronic ethanol consumption and alcohol metabolism also may influence various other metabolic pathways, thereby contributing to metabolic disorders frequently found in alcoholics, such as fatty liver and excessive levels of lipids in the blood (i.e., hyperlipidemia), accumulation of lactic acid in the body fluids (i.e., lactic acidosis), excessive production of chemical compounds known as ketones in the body (i.e., ketosis), and elevated levels of uric acid in the blood (i.e., hyperuricemia)

As the gastrointestinal tract is in direct contact with the environment, various environmental toxins can also impact the gut microbiome

Both protein kinase B (AKT) and DNA damage-inducing transcript 4 (DDIT4) are mammalian target of rapamycin (mTOR) regulators, which play an important role in the regulation of autophagy 35,36

doi: 10.1038/s41401-022-00902-w, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 137.Sheridan A, Nellenbach K, Pandit S, Byrnes E, Hardy G, Lutz H, et al