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Down syndrome Down syndrome is known to involve increased systemic oxidative stress (Busciglio and Yankner 1995)

Serum levels of IGF-1 are also modulated by Prolactin, placental lactogen, thyroid hormones and steroids, which act, at least in part, by influencing growth hormone levels

A.SalvatoreM.EmanuelssonO.WintherO.HeijneG

doi: 10.3390/cells8030204 232

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