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10.1371/journal.pone.0146797 Summary Keywords autism, folinic Acid, glutathione, methylation, methylcobalamin, oxidative stress, tetrahydrobiopterin Citation Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ and Frye RE (2018) Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials

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Introduction Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders worldwide, with an estimated lifetime prevalence of 10.8% [1], increasing to 19% among adolescents [2]