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Overexpression of TDP-43 can lead to motor deficits, neuronal loss, and gliosis in the motor cortex, with these effects being most severe in ApoE2 mice

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555 These vaccines were designed, manufactured, evaluated, and brought to market in an extremely short period compared with traditional vaccine development timelines, highlighting the unique advantages of mRNA vaccines, including high safety, simple design, broad target range, and ease of scaling up production
