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Additionally, molecular analysis indicated that up-regulation of -arrestin2, an intracellular protein involved in the desensitization and internalization of dopamine receptors and activation of alternative signaling pathways, may be associated with reduced severity of dyskinesia in levodopa-benserazide-loaded PLGA nanocarrier-treated PD rats

70 , 176 In contrast, polymeric carriers composed of synthetic or natural polymers such as PLGA or PEG enable controlled delivery of ferroptosis inducers (eg, erastin, RSL3, siRNA targeting GPX4 or plasmids encoding shGPX4) into the tumour microenvironment

But at the time, Sikiric was just a second-year medical student at the University of Zagreb School of Medicine in Croatia, listening to a lecture about the adrenal glands and the bodys response to stress