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170 In periosteum-derived skeletal progenitors, pharmacological inhibition of Complex III of the electron transport chain increased succinate and 2-hydroxyglutarate levels that inhibited ten-eleven translocation (TET) DNA demethylase activity, causing wide-spread DNA hypermethylation in the genome
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Bevacizumab was initially approved for the treatment of colon cancer but is now used as an off-label treatment of various cancers and blinding eye diseases 46
The lateral tail vein was cannulated using a heparinized 26G i.v
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