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Description
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Knocked down PINK1 in SHSY5Y cells results in inhibition of mDNA synthesis, disruption of key indicators of mitochondrial activity, mitochondrial membrane potential, and suppressed production of ATP (Gegg et al

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SIRT1 deficiency heightens susceptibility to NIHL and hair cell loss To investigate the role of SIRT1 in NIHL, we crossed cochlear hair cell-specific Gfi1-Cre ( Gfi1 cre/+ ) mice to obtain SIRT1 hair cell-specific knockout mice ( SIRT1 CKO) (Supplemental Fig
