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Eur Respir Rev 2015;24, 451-461

Peterle L, Sanfilippo S, Borgia F, Li Pomi F, Vadal R, Costa R, et al

In brief, PDLSCs were seeded in 6-well plates at a density of 2 10 5 cells/well and cultured until 6070% confluence, then those cells were transfected with siRNA targeting G6PDH (si-G6PDH) or negative control siRNA (NC) in the presence of transfection reagents (GenePharma)

For instance, MSC transplantation in these models has been shown to modulate the neuroinflammatory milieu by suppressing the activation of detrimental immune cells (58)

However, the health benefit of glutathione from natural sources derived from fruits and vegetables is still debated

GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig