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Peptide-driven proton sponge nano-assembly for imaging and triggering lysosome-regulated immunogenic cancer cell death

2019;51(11):e13432

At physiological pH, peroxynitrite will comprise a mixture of ONOO and the protonated peroxynitrous acid (ONOOH)

On the other hand, NPW treatment depressed the degree of lipid peroxidation, neutrophil infiltration and pro-inflammatory cytokine levels, and elevated antioxidant capacity in conjunction with the downregulation of gastric COX-1 and COX-2 mRNA levels, suggesting that improved gastric damage due to NPW could be eliminating the need for compensatory upregulation of COX enzymes

doi: 10.1016/j.jaut.2022.102867 91 MazziottaCTognonMMartiniFTorreggianiE

They may have tried dietary changes, supplements, or even stimulant medications, but still feel mentally dimmed. These individuals may have underlying oxidative stress or mitochondrial inefficiencies contributing to their cognitive symptoms