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Therapeutic modulation of epigenetic drivers of drug resistance in ovarian cancer

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Inhibition of cGAS-STING or type I IFN restores DHODH expression, reverses lipid peroxidation and ROS production, and rescues Mn 2+ -induced ferroptosis in tumor cells (148)

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ROS generation

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[Lipid peroxidation and activity of diagnostically significant enzymes in cosmonauts after flights of various durations]

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The C3 component can be either an aliphatic chain or part of a five- or six-membered oxygen-containing ring with C6 segments

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Systemic injection into abdominal fat also provides benefits, though potentially less concentrated at the specific injury site

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